Drug giant GlaxoSmithKline has reached a deal to acquire Bristol-Myers Squibb’s HIV portfolio.

GSK will pay $350 million up front and could pay an additional $1 billion depending on developmental and sales milestones.

GSK did the deal through its subsidiary ViiV Healthcare, a HIV specialty company established by GlaxoSmithKline and Pfizer in 2009.

It is actually two separate deals — one to buy BMS’s late-stage HIV assets and another to buy assets earlier in the developmental pipeline. The deals should close independently during the first half of 2016.

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